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Fresofol 1% Mct Lct Injection 20ml

Original price was: ₨3,200.00.Current price is: ₨3,000.00.

Pregnancy and Breastfeeding: Fresofol should only be used during pregnancy if necessary and under the supervision of a qualified medical professional. It is excreted in breast milk, so it is recommended that breastfeeding be delayed for a period after receiving Fresofol.

Description

Fresofol Injection Price in Pakistan

Fresofol Injection Price in Pakistan Fresofol is a brand name for the injectable formulation of propofol, a widely used general anesthetic. Propofol is a short-acting intravenous (IV) anesthetic agent that induces rapid sedation and general anesthesia. Fresofol is particularly favored for its ability to induce quick and controlled anesthesia with a fast recovery time, making it ideal for use in surgical, diagnostic, and intensive care settings. It is commonly used for the induction and maintenance of general anesthesia, as well as for sedation in critically ill patients.

Key Uses of Fresofol Injection

Fresofol injection is employed in various medical settings, including:

  1. Induction and Maintenance of General Anesthesia: Fresofol is used to induce general anesthesia in patients undergoing surgery. It is also used in maintaining anesthesia during the surgical procedure, especially for short to moderate-length surgeries.
  2. Sedation in Intensive Care Units (ICU): It is commonly used for sedation in critically ill patients who require mechanical ventilation in an ICU setting, helping to keep patients comfortable and relaxed during prolonged ventilatory support.
  3. Sedation for Diagnostic Procedures: Fresofol is also used for sedation during diagnostic and minor surgical procedures, such as endoscopies or dental treatments, where a rapid onset and quick recovery are desired.
  4. Procedural Sedation: In outpatient surgeries or short procedures, Fresofol can be used to achieve deep sedation, allowing the patient to remain comfortable while still being responsive to commands.

How Fresofol Works

Fresofol (propofol) works by enhancing the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA reduces brain activity, leading to sedation and unconsciousness. Propofol acts very quickly to produce anesthesia, usually within 30 seconds of administration.

Its short half-life and rapid metabolism by the liver allow for quick recovery once the infusion is stopped, which is particularly useful in cases where anesthesia needs to be reversed quickly for short procedures or when patients are in intensive care and need to be sedated for extended periods.

Dosage and Administration

Fresofol is administered intravenously and the dosage is adjusted according to the patient’s weight, age, medical condition, and the nature of the procedure. It is typically given as an initial bolus dose followed by a maintenance infusion. The infusion rates are adjusted to maintain the appropriate level of sedation or anesthesia.

  • Induction: For induction of general anesthesia in adults, an initial dose of 1.5–2.5 mg/kg is typically administered. For children, the dose may vary, and additional doses may be required to reach the desired level of anesthesia.
  • Maintenance: For maintenance of anesthesia, Fresofol is usually administered as a continuous infusion at a rate of 4–12 mg/kg/hr depending on the patient’s response.
  • Sedation: For sedation in intensive care or during procedures, lower doses are used, typically 0.3–4 mg/kg/hr.

The dosage may be adjusted to achieve the desired effect while minimizing side effects.

Advantages of Fresofol Injection

Fresofol offers several significant advantages over other anesthetic agents:

  1. Rapid Onset and Recovery: Fresofol provides fast induction of anesthesia, with patients typically becoming unconscious within 30 seconds of administration. Recovery is equally rapid, with patients often regaining consciousness within minutes of discontinuation.
  2. Predictable Effects: The effects of Fresofol are predictable and easy to titrate. Allowing anesthesiologists to carefully control the level of sedation or anesthesia during procedures.
  3. Minimal Postoperative Side Effects: Unlike other anesthetics, Fresofol is associated with fewer side effects such as nausea and vomiting after the procedure, making it an attractive option for outpatient surgeries.
  4. Less Accumulation: Since Fresofol has a short half-life and is rapidly metabolized, it is less likely to accumulate in the body during prolonged use, reducing the risk of prolonged sedation.

Potential Side Effects

While Fresofol is generally well-tolerated, it may cause some side effects, especially if administered incorrectly or in high doses. Some potential side effects include:

  • Common Side Effects:
    • Pain or irritation at the injection site.
    • Low blood pressure (hypotension).
    • Respiratory depression (slowed or difficulty breathing), especially if combined with other sedatives or analgesics.
    • Drowsiness or grogginess upon waking.
    • Nausea or vomiting in the postoperative phase.
  • Serious Side Effects (Rare but possible):
    • Severe allergic reactions, including rash, swelling, or difficulty breathing.
    • Bradycardia (slow heart rate), which may require medical intervention.
    • Myoclonus (muscle twitching or jerking).
    • Propofol Infusion Syndrome: A rare but serious condition that can occur during prolonged use, characterized by metabolic acidosis, cardiac arrhythmias, and organ failure.

Precautions

  1. Medical History: Patients should inform their healthcare provider if they have a history of heart problems, lung disease, or allergic reactions to anesthetics.
  2. Drug Interactions: Fresofol can interact with other sedatives, opioids, or muscle relaxants, potentially enhancing their effects. Careful adjustment of doses may be required when used in combination with other medications.

Conclusion

Fresofol injection (propofol) is a powerful, fast-acting anesthetic agent that is highly effective for the induction and maintenance of general anesthesia, as well as for sedation during medical procedures. Its rapid onset, predictable effects, and quick recovery time make it a preferred choice for both inpatient and outpatient procedures. When used appropriately, Fresofol provides a reliable and efficient means of managing anesthesia and sedation in various clinical settings.

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